- Fever, tachypnea, tachycardia
- Encephalopathy (Confusion, disorientation)
- Hypotension
- DIC
- Skin lesions (rash, petechae)
- Nausea, vomiting & diarrhea
- Signs of primary site (Infective)
- Cardio-pulmonary complications
- ARDS/Shock lung – severe hypoxemia
- Renal complications
- Oliguria, Azotemia, proteinuria, renal cortical necrosis
- Coagulation
- DIC
- Neurological complication
- Encephalopathy, coma
- Leukocytosis with left shift
- Deranged coagulation profile
- Deranged liver function test
- Deranged renal functions
- Metabolic acidosis nX-ray chest — Bilateral infiltrates (ARDS)
- ECG abnormalities
- No specific test
- History important
- Knowledge of likely organism involved
- Clinical examination very important
- Identification of infected areas
- Blood cultures…. Multiple sites
Effective antimicrobial agents
- Bacterial Culture
- Based on likely organism involved
Removal of source of infection
Infected sites, IV catheters, Foleys or drainage catheters
Haemodynamic
Organ perfusion- ionotropes, IV fluids
Respiratory
Ventilatory support
Metabolic support
Sodium bicarbonates
Treatment of DIC
Platelet and FFP transfusion
Prognosis
Severe sepsis 25-35% die
Septic shock 40-55% die
Septicemia – howMed
Effective antimicrobial agents
Removal of source of infection
Infected sites, IV catheters, Foleys or drainage catheters
Haemodynamic
Organ perfusion- ionotropes, IV fluids
Respiratory
Ventilatory support
Metabolic support
Sodium bicarbonates
Treatment of DIC
Platelet and FFP transfusion
Prognosis
Severe sepsis 25-35% die
Septic shock 40-55% die