Role of Triglyceride Metabolism in Development of Hyperlipidemia – howMed

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• Fatty acids are derived from the diet (exogenous) and the catabolism of carbohydrates, amino acids and other fatty acids (endogenous).
• After conversion to triglycerides they are transported in chylomicrons (exogenous pathway) and VLDL particles (endogenous pathway).

• Dietary triglycerides are emulsified in the gut and digested by lipases to fatty acids and monoglycerides, which are then absorbed unchanged.
• The short – chain fatty acids are directly absorbed into the portal circulation, whilst the long chain acids are reconverted to triglycerides and incorporated into chylomicrons.
• These particles are formed in the intestinal cells from triglycerides, apolipoproteins B-48, A-1 and A-II, and then secreted into the lymph.
• Cholesterol is also incorporated into the particle, and although it contributes