Nicotine and Lobeline – howMed

Alkaloids liquid in nature, obtained from plant source.

Actions are mainly on nicotinic receptors (CNS, PNS, NMJ)

CNS, have important effects on brainstem and cortex.

PNS – autonomic ganglia.

NMJ, immediate depolarization of the end plate – increase in permeability to sodium and potassium ions.

Parasympathomimetic Drugs

Acetylcholine

Carbachol

Methacholine

Bethanechol

Muscarine and Pilocarpine