Quaternary amine (Amanita muscaria)
Poorly soluble, less complete absorption from the GIT
Very toxic & can even enter the brain
Treatment of overdosage: Atropine, 1-2 mg parenterally
Pilocarpine
Tertiary amine (plant source; Pilocarpus jaborandi leaves)
Has muscarinic actions
Therapeutic uses:
- Glaucoma
- To reduce the effect of mydriatics
- To break adhesions
- Sjogren’s syndrome (Cevimeline)
Not used for systemic diseases because increased tracheo-bronchial secretions lead to pulmonary edema. It is highly lipid soluble usually given topically.
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Parasympathomimetic Drugs
Acetylcholine
Carbachol
Methacholine
Bethanechol
Nicotine and Lobeline
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Muscarine and Pilocarpine – howMed
Quaternary amine (Amanita muscaria)
Poorly soluble, less complete absorption from the GIT
Very toxic & can even enter the brain
Treatment of overdosage: Atropine, 1-2 mg parenterally
Pilocarpine
Tertiary amine (plant source; Pilocarpus jaborandi leaves)
Has muscarinic actions
Therapeutic uses:
Not used for systemic diseases because increased tracheo-bronchial secretions lead to pulmonary edema. It is highly lipid soluble usually given topically.
Continue Reading
Parasympathomimetic Drugs
Acetylcholine
Carbachol
Methacholine
Bethanechol
Nicotine and Lobeline
Browse all articles on Autonomic Nervous System