Hypertension -Pathophysiology, Causes and Complications – howMed

Normal Blood Pressure

100 mm Hg

Pathophysiology of Hypertension

Systolic blood pressure (SBP):

Correlates with stroke volume (SV) and compliance of aorta

i. Primary determinants of stroke volume:

Preload (volume of blood in left ventricle; LV)
Afterload (resistance LV contracts against)
Contractility of heart

ii. Vessel elasticity determines complaince of the aorta

iii. Increased Preload, increased contractility: SBP; increased preload, decreased contractility, decreased afterload: increased SBP

iv. Decreased Elasticity decreased of aorta (old age): increased SBP

Diastolic BP (DBP):

Represents volume of blood in the aorta in diastole

i. Depends on the vascular tone of the peripheral resistance arterioles.

ii. Vasoconstriction: increased DBP; vasodilation: decreased DBP

Vasoconstriction increases TPR

Increases diastolic blood pressure

Role of sodium in hypertension

i. Excess sodium increases plasma volume

Increases stroke volume and systolic blood pressure

ii. Excess sodium produces vasoconstriction of TPR arterioles

Sodium enters arteriole smooth muscle cells and opens calcium channels, causing vasoconstriction.
Increases diastolic blood pressure

Essential hypertension

Accounts for 95% of cases of hypertension

Pathogenesis

i. Genetic factors reduce renal sodium excretion

ii. Unknown factors cause vasoconstriction of arterioles

iii. Obesity, stress

Secondary hypertension

Accounts for 5% of cases of hypertension

Renovascular hypertension

i. Causes

Atherosclerotic plaque partially blocks blood flow at the renal artery orifice
Young to middle aged women
- Fibromuscular hyperplasia occurs in multifocal areas of the renal artery

ii. Pathogenesis

Decreased renal arterial blood flow activates the renin-angiotensin-aldosterone (RAA) system.
Angiotensin II vasoconstricts TPR arterioles.
Aldosterone increases sodium retention

iii. Clinical findings

a. Severe, uncontrollable hypertension b. Increased plasma renin activity (PRA)

c. Involved kidney has increased PRA in the renal vein

d. Uninvolved kidney has decreased PRA.

Increased plasma volume due to aldosterone excess suppresses RAA system in normal kidney

e. Epigastric bruit

Sound is due to turbulence of blood flow through the narrow renal artery

f. Angiography

Involved kidney shows diminished size (atrophy) and delayed emptying
Renal artery has “ beaded” appearance in fibromuscular hyperplasia

g. Other causes of secondary hypertension

Causes of Secondary Hypertension

System or source	Description
Adrenal	Cushing syndrome: increased mineralocorticoids Pheochromocytoma: increased catecholamines Neuroblastoma: increased catecholamines 11-Hydrocylase deficiency: increased mineralocorticoids (i.e. deoxycorticosterone) Primary aldosteronism (Conn’s syndrome): increased aldosterone
Aorta	Postductal coarctation: activalion of RAA system Elderly: systolic hyperlension due to decreased elasticity of lhe aorta
CNS	Inlracranial hypertension: release of catecholamines
Drugs	Oral contraceptive: increased synthesis of angiotensinogen; most common cause of hyperlension in young women Cocaine: increased sympathetic activity
Parathyroid	Primary hyperparathyroidism: calcium increases peripheral resistance arteriole smooth muscle cell contraction
Pregnancy	Preeclampsia: increased angiotensin II
Renal	Renovascular disease: atherosclerosis (elderly men), fibromuscular hyperplasia (women) Renal parenchymal disease: e,g,, diabetic nephropathy, adull polycystic kidney disease, glomerulonephritis; retenlion of sodium
Thyroid	Craves’ disease: systolic hypertension from increased cardiac conlraction Hypothyroidism: diastolic hypertension due to retention of sodium

RAA. renin-angiotensin-aldosterone

Complications of Hypertension

System	Complications
Cardiovascular	Left ventricular hyperlrophy; most common overall complication Acute myocardial infarction: most common cause of death Atherosclerosis
Central nervous	Intracerebral hematoma: due to rupiure of Charcot-Bouchard aneurysms Berry aneurysm: rupiure produces a subarachnoid hemorrhage Lacunar infarcts: small infarcts due to hyaline arteriolosclerosis
Renal	Benign nephrosclerosis: kidney disease of hypertension; due to hyaline arteriolosclerosis; atrophy of tubules and sclerosis of glomeruli; progresses to renal failure Malignant hypertension: rapid increase in blood pressure accompanied by renal failure and cerebral edema
Eyes	Hypertensive retinopathy: arteriovenous nicking, hemorrhage of retinal vessels, exudates (increased vessel permeability, retinal infarction), papilledema