Classification of Tumors of Colon and Rectum – howMed

Tumors of colon and rectum may be classified, based on histology, into:

1.    Epithelial tumors:

a.    Adenoma: i.    Tubular ii.   Villous iii.  Tubulovillous

iv.  Serrated

b.    Intraepithelial neoplasia (dysplasia) associated with chronic inflammatory diseases i.    Low-grade glandular intraepithelial neoplasia

ii.    High-grade glandular intraepithelial neoplasia

c.    Carcinoma i.     Adenocarcinoma ii.    Mucinous carcinoma iii.   Signet-ring carcinoma iv.   Small cell carcinoma v.    Squamous cell carcinoma vi.   Adenosquamous carcinoma vii.  Medullary carcinoma

viii. Undifferentiated carcinoma

d.    Carcinoid tumor (Well differentiated endocrine neoplasia) i.    EC cells, serotonin producing neoplasm ii.    L-cell, glucagonlike peptide and PP/PYY producing tumour

iii.    Others

e.    Mixed carcinoid-adenocarcinoma

f.    Others

2.    Non-Epithelial tumors

a.    Lipoma b.    Leiomyoma c.    Gastrointestinal stromal tumour d.    Leiomyosarcoma e.    Angiosarcoma f.    Kaposi sarcoma g.    Malignanat melanoma h.    Others

i.    Malignant Lymphomas:

• Marginal zone B-cell lymphoma of MALT type
• Mantle cell lymphoma
• Diffuse large B-cell lymphoma
• Burkitt lymphoma
• Burkitt-like/atypical Burkitt lymphoma
• Others

3.    Secondary Tumors
4.    Polyps:

a.    Hyperplastic polyps (metaplastic) b.    Peutz-Jeghers

c.    Juvenile polyps