Structure related to Acetylcholine, acetate is replaced by carbamate & choline is methylated, thus it is carbomyl beta methyl choline.
It has no nicotinic actions
Muscarinic actions are prominent on eye, GIT & urinary bladder
Prolonged duration of action because is more resistant to hydrolysis.
Duration of action is one hour.
Therapeutic uses:
1. Post operative gastric distension
2. Paralytic ileus
3. Bladder atonia
4. Megacolon
It is given subcutaneously in 5 mg dose. Neostigmine is also given for these conditions (15 mg oral, 0.5-1 mg subcutaneously)
Mechanism of action is like carbamates.
Toxicity includes bronchospasm, it does not enter CNS.
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Parasympathomimetic Drugs
Acetylcholine
Carbachol
Methacholine
Muscarine and Pilocarpine
Nicotine and Lobeline
Browse all articles on Autonomic Nervous System
Bethanechol – howMed
Structure related to Acetylcholine, acetate is replaced by carbamate & choline is methylated, thus it is carbomyl beta methyl choline.
It has no nicotinic actions
Muscarinic actions are prominent on eye, GIT & urinary bladder
Prolonged duration of action because is more resistant to hydrolysis.
Duration of action is one hour.
Therapeutic uses:
1. Post operative gastric distension
2. Paralytic ileus
3. Bladder atonia
4. Megacolon
It is given subcutaneously in 5 mg dose. Neostigmine is also given for these conditions (15 mg oral, 0.5-1 mg subcutaneously)
Mechanism of action is like carbamates.
Toxicity includes bronchospasm, it does not enter CNS.
Continue Reading
Parasympathomimetic Drugs
Acetylcholine
Carbachol
Methacholine
Muscarine and Pilocarpine
Nicotine and Lobeline
Browse all articles on Autonomic Nervous System